supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Isoflurophate
supplement:
Serine
Research Papers that Mention the Interaction
“It was observed that the serine residue modifier di-isopropyl fluorophosphate dose-dependently inhibited activity, implicating a serine residue in the catalytic action.”
Identification of a novel amidase motif in neutral ceramidase.“A form of thrombin in which the active site serine has been blocked by diisopropyl fluorophosphate binds to haemadin, but with a 72000-fold reduced affinity, indicating that the N-terminus is more important than the C-terminus for strong binding.”
“Studies on different derivatives of hydrolytic enzymes, such as chymotrypsin, trypsin, elastase and thrombin have shown an “active …” residue to be part of the catalytic sites of these Blockage of the hydroxyl group of this serine residue with, ….g., diisopropylfluorophosphate (DFP) leads to the complete loss of catalytic activity.”
“The enzyme is inactivated by diisopropyl phosphorofluoridate , which covalently modifies the serine residue corresponding to position 478, identifying this as the active site serine residue.(ABSTRACT TRUNCATED AT 250 WORDS)”
“One molecule of DFP binds to the hydroxyl group of a serine residue in the active site of the enzyme and one molecule of HF is liberated.”
“All of these enzymes have a serine residue at or near the catalytic site as they are strongly inhibited by diisopropyl fluorophosphate.”
Isolation and characterization of four lipolytic preparations from rat skeletal muscle.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback