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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Isoflurane
supplement:
Tyrosine
Research Papers that Mention the Interaction
“Mutation of serine residue 294 within the TM2 to histidine or tyrosine increased the potency of GABA and decreased positive modulation by isoflurane.”
Transmembrane residues define the action of isoflurane at the GABAA receptor alpha-3 subunit“Results:Clinically relevant concentrations of thiopental, propofol, etomidate, isoflurane , sevoflurane, and desflurane induced a concentration-related increase in tyrosine phosphorylation.”
Effects of Anesthetic Agents on Focal Adhesion Kinase (pp125FAK) Tyrosine Phosphorylation in Rat Hippocampal Slices“Conclusion:The … study, that isoflurane dose-dependently inhibits … contraction and tyrosine phosphorylation of a set of proteins including PLCγ-1 and p42MAPK in rat aortic smooth muscle, suggest that isoflurane …–modulated contraction of vascular smooth muscle, especially that mediated by the tyrosine-phosphorylated PLCγ-1 and MAPK signaling pathways.”
“When tyrosine 403 was replaced by histidine (Y403H), volatile anesthetics ( isoflurane or halothane) at clinically relevant concentrations significantly decreased the transporter activity.”
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