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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Isoflurane
supplement:
Taurine
Research Papers that Mention the Interaction
“We used outside-out patch-clamp single channel electrophysiology to investigate the mechanism of action of 200 mM ethanol and 0.55 mM isoflurane in enhancing the effects of a saturating concentration of taurine.”
Single Channel Analysis of Isoflurane and Ethanol Enhancement of Taurine-Activated Glycine Receptors“4 Isoflurane also potentiated responses to taurine , a partial agonist at the glycine receptor.”
“The EC50 concentration decreased from a control value of 1.6 ± 0.2 to 0.9 ± 0.1 mM taurine in the presence of 305 μm isoflurane , while the maximum response to taurine increased from 47 ± 2 to 59 ± 2% of the maximum response to glycine.”
“Moreover, isoflurane caused spatial working memory deficits in aged rats, which were prevented by taurine pretreatment.”
Taurine Pretreatment Prevents Isoflurane-Induced Cognitive Impairment by Inhibiting ER Stress-Mediated Activation of Apoptosis Pathways in the Hippocampus in Aged Rats“ Isoflurane prevented the ischemia-induced efflux of glutamate and reduced the release of taurine.”
“ Isoflurane reduced the release of taurine and most of the other amino acids.”
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