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Last Updated: 2 years ago

Possible Interaction: Isoflurane and Taurine

supplement:

Taurine

Research Papers that Mention the Interaction

We used outside-out patch-clamp single channel electrophysiology to investigate the mechanism of action of 200 mM ethanol and 0.55 mM isoflurane in enhancing the effects of a saturating concentration of taurine.
The Journal of Pharmacology and Experimental Therapeutics  •  2018  |  View Paper
4 Isoflurane also potentiated responses to taurine , a partial agonist at the glycine receptor.
The EC50 concentration decreased from a control value of 1.6 ± 0.2 to 0.9 ± 0.1 mM taurine in the presence of 305 μm isoflurane , while the maximum response to taurine increased from 47 ± 2 to 59 ± 2% of the maximum response to glycine.
British journal of pharmacology  •  1996  |  View Paper
Moreover, isoflurane caused spatial working memory deficits in aged rats, which were prevented by taurine pretreatment.
Neurochemical Research  •  2016  |  View Paper
Isoflurane prevented the ischemia-induced efflux of glutamate and reduced the release of taurine.
The International journal of neuroscience  •  2006  |  View Paper
Isoflurane reduced the release of taurine and most of the other amino acids.
Journal of neurosurgical anesthesiology  •  1998  |  View Paper