supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Isoflurane
supplement:
NADH
Research Papers that Mention the Interaction
“Unlike AA, ISO reduced the magnitude of state 3 NADH oxidation with PM or SUC as substrate.”
“We found that … PM, ISO and ROT similarly decreased … of state 3 NADH oxidation and increased the duration of state 3 NADH oxidation, ΔΨm depolarization, and respiration in a concentration-dependent … with substrate SUC, ISO and ROT decreased the duration of state 3 NADH oxidation, ΔΨm depolarization and respiration.”
Isoflurane modulates cardiac mitochondrial bioenergetics by selectively attenuating respiratory complexes.“Halothane, isoflurane and sevoflurane dose‐dependently inhibited NADH :DBQ oxidoreductase activity.”
“Unlike the classical inhibitor rotenone, none of the anaesthetics completely inhibited enzyme activity at high concentration, suggesting that these agents bind weakly to the ‘hydrophobic inhibitory site’ of complex I. In conclusion, halothane, isoflurane and sevoflurane inhibit complex I ( NADH :ubiquinone oxidoreductase) of the electron transport chain.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback