supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago
drug:
Isoflurane
supplement:
Leucine
Research Papers that Mention the Interaction
“Background:Myocardial L-type Ca2+ currents (ICa L ) are inhibited by isoflurane in the presence of a partial pressure of oxygen (Po2) of 150 mmHg.”
Oxygen Tension Modulates Inhibition of L-type Calcium Currents by Isoflurane in Human Atrial Cardiomyocytes“ Isoflurane preconditioning increased the expression of the anti-apoptotic proteins Bcl-2 and Bcl-X L and reduced apoptosis in neurones.”
“ Isoflurane preconditioning can reduce the cathepsin L in plasma caused by ischemia-reperfusion injury.”
[Cathepsin L expression in plasma after acute myocardial ischemia and ischemia-reperfusion in rats].“However, the plasma L concentrations were less than predicted, as was the MAC reduction with L. CLINICAL RELEVANCE The use of L , K and the combination, at the doses studied, will allow a clinically important reduction in the concentration of ISO required to maintain general anesthesia in goats.”
“Both ICa L inactivation and IKdr activation kinetics were accelerated by isoflurane.”
“At 1.…, isoflurane caused a significant (P < 0.05) … state activation in ventricular ICa, L but not in atrial ICa,L or ICa,T. In addition to the depression of ICa,L, … hyperpolarizing shift in the reversal potential of ICa for both atrial and ventricular L-type calcium channels.”
“ Isoflurane preconditioning can reduce the cathepsin L in plasma caused by ischemia-reperfusion injury.”
[Cathepsin L expression in plasma after acute myocardial ischemia and ischemia-reperfusion in rats].
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback