Possible Interaction: Isoflurane and Calcium Supplement

“Pretreatment with the L-type Ca2+ channel agonist, Bay K 8644, attenuated the inhibition of P-CREB formation by isoflurane.”

“Franks JJ, Horn J-L, Janicki PK, Singh G: Halothane, isoflurane , xenon and nitrous oxide inhibit calcium ATPase pump activity in rat brain synaptic plasma membranes.”

“In this study, we treated neuronal cells with isoflurane for 6 h. We found that isoflurane induced the opening of mitochondrial permeability transition pores, increased the levels of reactive oxygen species and the activation of caspase‑3, and decreased the mitochondrial membrane potential and the intracellular calcium ion concentration.”

“ Isoflurane depletes calcium from sarcoplasmic reticulum (SR) of muscle, an analogue of ER in neurons, while sevoflurane maintains or increases SR calcium.”

“CONCLUSIONS Is flurane de creased AngII-induced Ca mo bilization at clinically relevant concentrations, suggesting that vascular response to AngII could be altered during isoflurane anesthesia.”

“Halothane, enflurane, and isoflurane all enhance, while sevoflurane attenuates, the Ca2+ -induced Ca2+-release mechanism.”

“Plasma ionized calcium concentration was lower after exercise, compared with baseline values, and remained lower at 30 minutes of isoflurane anesthesia.”

“Results Isoflurane (1-5%) dose dependently increased (24-81%) the Ca (2+-activated) force.”

“Potentiation of IK Ca may preclude significant membrane activation during the onset of isoflurane's action. (”

“Since isoflurane reduces IK, Ca coincident with suppression of Ca2+ channel current, it was concluded that the depression of IK,Ca by isoflurane is of secondary importance to reduction in inward Ca2+ channel current.”

“In contrast, Ca 2 + uptake is only modestly decreased by isoflurane , a finding consistent with other studies in myocardial tissue that suggest isoflurane has less effect on Ca 2+ stores.”