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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Isoflavones
drug:
Uridine Triacetate
Research Papers that Mention the Interaction
“Furthermore, the treatment of cells with isoflavones significantly reduced the microtubule-associated protein tau hyperphosphorylation by inactivating glycogen synthase kinase-3β and activating serine/threonine-protein phosphatase 2A.”
Protective effect of isoflavones against homocysteine-mediated neuronal degeneration in SH-SY5Y cells“In conclusion, our results clearly demonstrate that isoflavones prevent ER stress-mediated neurotoxicity by inhibiting tau hyperphosphorylation in SH-SY5Y cells.”
“TM activated glycogen synthase kinase 3beta (GSK3beta), a kinase involved in tau phosphorylation; in contrast, isoflavones inactivated GSK3beta and decreased tau hyperphosphorylation.”
“The antioxidant activity of isoflavones may be effective in preventing dementia by inhibiting the phosphorylation of Alzheimer’s-related tau proteins.”
Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans“Additional TEM experiment confirmed that ortho-catechol containing isoflavone 4d significantly prevented the aggregation of both Aβ and tau.”
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