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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Isoflavones
drug:
Tamoxifen
Research Papers that Mention the Interaction
“These findings suggest that simultaneous consumption of isoflavone supplements with TAM may not be safe.”
The Effect of the Phytoestrogens Genistein, Daidzein, and Equol on the Growth of Tamoxifen-Resistant T47D/PKCα“Clinical findings indicate potential benefits of isoflavone exposure even during breast cancer treatment with tamoxifen or anastrozole.”
“Furthermore, in drug interaction studies daidzin-rich isoflavone extracts antagonized tamoxifen , an ER inhibitor.”
“However, the estrogen-like effect of isoflavones and the potential interaction between isoflavones and tamoxifen have led to concern about soy food consumption among breast cancer patients.”
“A combination of three (genistein, daidzein, and glycitein) to five isoflavones (plus biochanin A and formononetin) inhibited tamoxifen α-hydroxylation to a greater extent but did not decrease the formation of identified metabolites.”
“Genistein and its isoflavone analogs have the potential to decrease side effects of tamoxifen through metabolic interactions that inhibit the formation of α-hydroxytamoxifen via inhibition of CYP1A2.”
Potential Beneficial Metabolic Interactions Between Tamoxifen and Isoflavones via Cytochrome P450-mediated Pathways in Female Rat Liver Microsomes
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