Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Isoflavones and Tamoxifen



Research Papers that Mention the Interaction

These findings suggest that simultaneous consumption of isoflavone supplements with TAM may not be safe.
Nutrition and cancer  •  2007  |  View Paper
Clinical findings indicate potential benefits of isoflavone exposure even during breast cancer treatment with tamoxifen or anastrozole.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology  •  2016  |  View Paper
Furthermore, in drug interaction studies daidzin-rich isoflavone extracts antagonized tamoxifen , an ER inhibitor.
Nutrition and cancer  •  2016  |  View Paper
However, the estrogen-like effect of isoflavones and the potential interaction between isoflavones and tamoxifen have led to concern about soy food consumption among breast cancer patients.
JAMA  •  2009  |  View Paper
A combination of three (genistein, daidzein, and glycitein) to five isoflavones (plus biochanin A and formononetin) inhibited tamoxifen α-hydroxylation to a greater extent but did not decrease the formation of identified metabolites.
Genistein and its isoflavone analogs have the potential to decrease side effects of tamoxifen through metabolic interactions that inhibit the formation of α-hydroxytamoxifen via inhibition of CYP1A2.
Pharmaceutical Research  •  2004  |  View Paper