Possible Interaction: Isoflavones and Soy Isoflavones

“Plasma arginine concentrations, the arginine-to-lysine ratio, and plasma isoflavone concentrations were higher after ISP consumption (P < 0.05).”

“The phosphorylation of AKT and S6 were decreased after soy isoflavone treatment in vivo and in vitro, suggesting an inhibition effect of soy isoflavones on mTORC1 activity.”

“Reviewed data show evidence of a beneficial effect of isoflavones on bone health in peri- and postmenopausal women when high-isoflavone soy protein is incorporated in the diet.”

“ SPI consumption increased urinary isoflavones compared with MPI.”

“This variation in the metabolism of soy isoflavones might cause differences in the beneficial effects of soy foods and isoflavones and therefore this should be considered in science and practice.”

“Despite the results from epidemiologic studies indicating a reduced risk of breast cancer associated with soy isoflavone intake, the estrogenic effect of soy isoflavones has raised concern for a potential increased risk of breast cancer in Western countries, where usual soy consumption is low.”

“Plasma isoflavone levels increased in subjects treated with soy isoflavones compared to baseline and to placebo, although intersubject variability in plasma levels was large.”

“The findings suggest that soy isoflavones may reduce lipid peroxidation in an age-dependent manner, with greater effects in older women, and with lower doses of isoflavones.”

“Conclusions: These results indicate that genistein and related soy isoflavones reactivate methylation-silenced genes, partially through a direct inhibition of DNA methyltransferase, which may contribute to the chemopreventive activity of dietary isoflavones.”

“Serum LDL cholesterol … who consumed SPI (mean 50 … high isoflavone content (mean intake 96 mg/d) decreased by 0.15 mmol/L (95% CI: 0.08 to 0.23 mmol/….0001) compared with those who consumed the same SPI level with low isoflavone content (mean intake 6 mg/d).”