Possible Interaction: Isoflavones and Nitric Oxide

“ Prenylated isoflavone derivatives (1-16) displayed remarkable inhibitory effects against nitric oxide (NO) production with the IC50 values ranging from 0.89 ± 0.05 to 8.49 ± 0.18 μM, comparable to that of the positive control (hydrocortisone).”

“Many isoflavones have anti-oxidative effects and anti-inflammatory actions, as well as induce nitric oxide production to maintain a healthy endothelium and prevent endothelial cell dysfunction.”

“In a macrophage cell line (RAW 264.7) activated with interferon gamma plus lipopolysaccharide, both isoflavones were found to inhibit NO production and tumour necrosis factor alpha (TNF-alpha) secretion dose-dependently, but they did not affect mRNA levels for inducible nitric oxide synthase and cyclo-oxygenase-2.”

“Estrogen-like compounds such as isoflavones are also suggested for increasing nitric oxide production.”

“BACKGROUND Isoflavones , having chemical structures similar to estrogens, are believed to stimulate nitric oxide production and thus lower blood pressure.”

“Therefore, these isoflavones can potentially act as an NO promoter and as an antioxidant.”

“3 We hypothesized that isoflavones may affect the expression of endothelial‐type nitric oxide synthase (eNOS) and thereby NO formation in vitro.”

“ Isoflavone induced inducible nitric oxide synthase expression, which led to increased nitric oxide level.”

“The isoflavone genistein 1 and some derivatives modulate IL-12, TNF-α and NO production by macrophages and lung cancer cell lines, and improve the clinical signs of experimental autoimmune encephalomyelitis (EAE).”

“Polymeric proanthocyanidins, but not isoflavones , at a concentration comparable with their content in HPE, inhibited NO , PGE2, and TNF-α formation, as well as activation of IκB-α.”