Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Isoflavones and Nitric Oxide

supplement:

Isoflavones

Research Papers that Mention the Interaction

Prenylated isoflavone derivatives (1-16) displayed remarkable inhibitory effects against nitric oxide (NO) production with the IC50 values ranging from 0.89 ± 0.05 to 8.49 ± 0.18 μM, comparable to that of the positive control (hydrocortisone).
Journal of agricultural and food chemistry  •  2019  |  View Paper
In a macrophage cell line (RAW 264.7) activated with interferon gamma plus lipopolysaccharide, both isoflavones were found to inhibit NO production and tumour necrosis factor alpha (TNF-alpha) secretion dose-dependently, but they did not affect mRNA levels for inducible nitric oxide synthase and cyclo-oxygenase-2.
The British journal of nutrition  •  2003  |  View Paper
Estrogen-like compounds such as isoflavones are also suggested for increasing nitric oxide production.
Climacteric : the journal of the International Menopause Society  •  2015  |  View Paper
BACKGROUND Isoflavones , having chemical structures similar to estrogens, are believed to stimulate nitric oxide production and thus lower blood pressure.
The American journal of clinical nutrition  •  2012  |  View Paper
Therefore, these isoflavones can potentially act as an NO promoter and as an antioxidant.
Menopause  •  2009  |  View Paper
3 We hypothesized that isoflavones may affect the expression of endothelial‐type nitric oxide synthase (eNOS) and thereby NO formation in vitro.
British journal of pharmacology  •  2005  |  View Paper
Isoflavone induced inducible nitric oxide synthase expression, which led to increased nitric oxide level.
Journal of animal physiology and animal nutrition  •  2016  |  View Paper
The isoflavone genistein 1 and some derivatives modulate IL-12, TNF-α and NO production by macrophages and lung cancer cell lines, and improve the clinical signs of experimental autoimmune encephalomyelitis (EAE).
European journal of medicinal chemistry  •  2014  |  View Paper
Polymeric proanthocyanidins, but not isoflavones , at a concentration comparable with their content in HPE, inhibited NO , PGE2, and TNF-α formation, as well as activation of IκB-α.
European Journal of Nutrition  •  2011  |  View Paper
In conclusion, isoflavone modulates the inflammatory response in activated macrophages by inhibiting NO and PGE(2) and by modulating the expression of key genes defined by transcriptomic profiling.
Journal of pharmaceutical and biomedical analysis  •  2010  |  View Paper
Show More