Possible Interaction: Isoflavones and Lignans

“Urinary excretion of isoflavonoids and lignans significantly increased with increased isoflavone consumption.”

“ Isoflavone metabolism could be correlated with the metabolism of lignans and ellagitannins.”

“Human studies demonstrate inverse associations between lignans and isoflavones and hormone-dependent cancers, cardiovascular disease, and osteoporosis1, and improvements in asthma control are reported in those with high soy consumption3.”

“These observations together with our findings suggest that the bacterial metabolites of lignans and isoflavones , in particular enterolactone, may have a causal role in disease prevention and control.”

“This prompt effect is probably due to the different pharmacokinetic properties of isoflavones and lignans; isoflavones are absorbed faster than lignans , while lignans are removed later.”

“In human subjects, even those on controlled diets, there is large interindividual variation in the metabolism of isoflavones and lignans , particularly in the production of the gut bacterial metabolite equol (from daidzein).”

“Results indicate lignan accumulation in tissues occurs, and coadministration of lignans with isoflavones affects the metabolite profile, with effects dependent on tissue type.”

“Although the intake of isoflavones and lignans may affect breast cancer treatment and prognosis—and associations may differ by menopausal status—postdiagnosis intake data are limited.”

“Six plant lignans, i.e., secoisolariciresinol, matairesinol, syringaresinol, lariciresinol, isolariciresinol, and pinoresinol, have been identified and quantified by gas chromatography-mass spectrometry, and a positive correlation has been found between the levels of plant lignans and the levels of isoflavones in the different products.”