Possible Interaction: Isoflavones and Genistein

“These results indicate that genistein can improve HD phenotype in patient-derived cells, and substantiates the need for further studies of this isoflavone as a potential therapeutic agent.”

“ Urinary isoflavones daidzein, genistein , and glycitein increased in a dose-dependent manner.”

“ Isoflavones inversely moderated calcium effects on systolic blood pressure (SBP) (interaction … β-estimates: − 3.1 for DE, − 12.86 for GE , all P < 0.05), and decreased diastolic blood pressure (DBP) (β-estimates: − 0.84 for DE, − 2.82 for GE, all P < 0.05) after controlling for calcium.”

“Null associations were also observed between intake of the individual isoflavones daidzein, genistein and glycitein and NPC risk, with adjusted odds ratios for the extreme quartiles ranging between 0.73 and 1.23.”

“Serum concentrations of isoflavone metabolites, genistein and daidzein, of the intervention group were remarkably elevated following intake of isoflavones (p < 0.001).”

“… serum isoflavones at 3 and 6 months from baseline in the Soy arm only, with approximately twofold increases in … to 93.9 [mean 16.9 ng/mL, 95% CI: 9.9 to 23.8]) and genistein (mean=100.4 nmol/L, 95% CI: …: 16.5 to 37.8]) concentrations.”

“ Plasma genistein and daidzein levels, but not equol, increased with isoflavone administration.”

“Plasma levels of genistein and daidzein (P < 0.001), but not equol, increased with isoflavone administration.”

“ Serum genistein significantly increased after consuming both isoflavone doses.”

“ Isoflavones and their aglycones ( genistein and daidzein) were significantly associated with decreased risk.”

“Consumption of tempeh (mainly isoflavone aglycon) resulted in higher serum peak levels of both daidzein (P < 0.001) and genistein (P < 0.01) and the associated area under the curve (P < 0.001 and P < 0.03, respectively) compared with textured vegetable protein (predominantly isoflavone glucosides).”