Possible Interaction: Isoflavones and Fructooligosaccharide

“Enhancement of IF bioavailability, following FOS fermentation, is probably involved.”

“Simultaneous FOS consumption improved IF protective effect on the skeleton, with the lowest IF dose becoming efficient.”

“Our findings suggest that although a genistin-rich isoflavones diet can increase the BMD in rats with Ovx-induced bone loss, combination of genistin-rich isoflavones and FOS had greater effect in preventing bone loss in this rat model.”

“The combination of genistin-rich isoflavones diet and 5% FOS further increased whole-body, right femur, and fourth lumbar BMD more compared to the genistin-rich isoflavones diet.”

“An additive effect of dietary isoflavone conjugates and FOS was observed by dual-energy X-ray absorptiometry in the distal part of the femur and in trabecular bone, by peripheral quantitative computed tomography.”

“In a previous study, FOS modified the absorption and enterohepatic recirculation of isoflavones in rats.”

“These results suggest that FOS increase the bioavailability of isoflavones , leading to cooperative effects in the prevention of osteopenia in OVX mice.”

“ FOS modified the absorption and enterohepatic recirculation of isoflavones.”

“ Fructooligosaccharides stimulate the growth of Bifidobacteria, which cleave isoflavone glycosides to yield corresponding aglycones, and convert metabolites by enhancing enterohepatic recirculation of isoflavones in rats.”

“ Isoflavone and fructooligosaccharides exhibited a synergistic in the distal metaphyseal trabecular bone, indicated by peripheral quantitative computed tomography.”

“These results indicate that isoflavone alone did not inhibit postgastrectomy osteopenia, but the combination of isoflavone and fructooligosaccharides improved the inhibition of trabecular bone loss by increasing calcium absorption and equol production through fructooligosaccharides supplementation.”