Possible Interaction: Isoflavones and Daidzein

“Furthermore, the data suggest that the metabolism of daidzein may be altered by the chemical composition of the isoflavones ingested.”

“ Daidzein and genistein glucuronides (DG and GG), major isoflavone metabolites, may be partly responsible for biological effects of isoflavones , such as estrogen receptor binding and natural killer cell (NK) activation or inhibition.”

“ Isoflavones inversely moderated calcium effects on systolic blood pressure (…) (interaction term β-estimates: − 3.1 for DE , − 12.86 for GE, all P < 0.05), and decreased diastolic blood pressure (DBP) (β-estimates: − 0.84 for DE, − 2.82 for GE, all P < 0.05) after controlling for calcium.”

“Serum concentrations of isoflavone metabolites, genistein and daidzein , of the intervention group were remarkably elevated following intake of isoflavones (p < 0.001).”

“Plasma levels of genistein and daidzein (P < 0.001), but not equol, increased with isoflavone administration.”

“ Isoflavones and their aglycones (genistein and daidzein ) were significantly associated with decreased risk.”

“Consumption of tempeh (mainly isoflavone aglycon) resulted in higher serum peak levels of both daidzein (P < 0.001) and genistein (P < 0.01) and the associated area under the curve (P < 0.001 and P < 0.03, respectively) compared with textured vegetable protein (predominantly isoflavone glucosides).”

“Daidzein is present in a very small amount in PLRE, but various glycosidic isoflavones , including puerarin, may release daidzein after metabolism.”

“ Daidzein , however, has a superior neuron-protective effect to other isoflavones.”

“The urinary excretion of daidzein and genistein was significantly increased with increasing levels of dietary isoflavones.”