Possible Interaction: Isoflavones and Calcium Supplement

“In conclusion, isoflavones combined with high Ca are more protective against the loss of femur and vertebra BMD than isoflavones or high Ca diet alone.”

“ Isoflavones inversely moderated calcium effects on systolic blood pressure (SBP) (interaction term β-estimates: − 3.1 for DE, − 12.86 for GE, all P < 0.…), and decreased diastolic blood pressure (DBP) (β-estimates: − 0.84 for DE, − 2.82 for GE, all P < 0.05) after controlling for calcium.”

“Moderation by isoflavones of the physiological effect of calcium tends to normalize SBP, and this effect is most significant when calcium concentrations are at the upper and lower limits of the physiological norm.”

“After intervention, compared with control, isoflavone and calcium groups, mean changes from their corresponding baseline values of BMD, calcium/phosphorus, vitamin D and … (GSH-pX) activity were significantly increased, however, those of phosphorus, osteocalcin, luteinizing hormone (LH) and follicle stimulating hormone (FSH) were significantly decreased in isoflavone … calcium group.”

“An inhibition study of several carbonic anhydrase CA , EC 4.2.1.1) isoforms with flavones and aminoflavones , compounds possessing a rather similar scaffold with the coumarins, recently discovered inhibitors of this enzyme, is reported.”

“The present results therefore suggest that non-soya isoflavones are associated with bone density independent of Ca, whereas the association with soya or soya isoflavones is affected by dietary Ca.”

“The present study indicated that isoflavone-enriched milk may have a partial preventive effect on ovariectomy-induced bone loss; however, vitamins D and K and Ca enrichment with isoflavone may enhance effectiveness for increasing bone mass in OVX rats.”