Possible Interaction: Iron-Dextran Complex and Iron, Dietary

“Guinea-pigs overloaded with iron by injections of iron dextran developed significantly reduced hepatic ascorbic acid concentrations and bone mineral densities; percentage bone-formation surface was significantly diminished and percentage bone-resorption surface significantly increased.”

“Besides anaphylactic reactions that were reported to occur in less than 1% of patients treated with iron dextran and have not been associated with other iron formulations, concerns about the long-term use of iron include the increased risk of infections and oxidative stress with consequent cardiovascular disease.”

“While oral iron has been disappointing in this regard, parenteral iron has been widely used, despite a significant incidence of severe side effects when iron dextran is used.”

“ iron is administered have led to a reduction in severe or fatal reactions common with iron dextran products.”

“The slow release of iron from this complex necessitates a delay in monitoring iron indices after the administration of large doses of iron dextran.”

“Twenty-four of the 40 (60%) showed massive iron loading and a significant direct correlation was found between iron loading and the amount of intravenous iron dextran administered.”

“Also, we demonstrated that the increased iron as well as dichlorofluorescein and 8-isoprostane levels in all four brain regions, induced by injection of iron dextran , could be effectively prevented by pre-treatment of the rats with ad-hepcidin.”

“ Iron loading was exacerbated after the administration of iron dextran or phenylhydrazine.”

“The results showed that iron dextran overload increased the iron content in the SN, decreased dopamine release and content, and reduced the numbers of TH-immunoreactive neurons.”

“ Iron-dextran produced a dramatic increase (6.7-fold) in plasma iron content, overwhelming the plasma total iron binding capacity.”