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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Iron, Dietary
supplement:
Zinc Cation
Research Papers that Mention the Interaction
“We speculate that Zn(II ) acts by interfering with the redox cycling of iron , possibly by competing with the latter for membrane binding sites.”
Inhibitory effect of zinc(II) on free radical lipid peroxidation in erythrocyte membranes.“The transition metals, Zn2+ , Co2+ and Ni2+, inhibited Fe uptake when used at 10 and 100 times the concentration of Fe.”
Characterisation of non-transferrin-bound iron (ferric citrate) uptake by rat hepatocytes in culture.“Here, we demonstrate that biofilm formation can be impaired by the addition of divalent metal ions, such as Zn(II) and Co(II), which inhibit iron uptake by virtue of their higher-than-iron affinity for the master controller protein of iron uptake, Fur.”
Abolition of Biofilm Formation in Urinary Tract Escherichia coli and Klebsiella Isolates by Metal Interference through Competition for Fur“The uptake of Fe increased with increasing Zn2+ and Cd2+ concentrations in single treatment, while decreased in compound treatment.”
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