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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Iron, Dietary
supplement:
Vitamin C
Research Papers that Mention the Interaction
“However, Vitamin C can act as a pro-oxidant in the presence of iron.”
“Long-term safety studies of IV iron co-administered with Vitamin C are warranted.”
Effect of intravenous vitamin C on cytokine activation and oxidative stress in end-stage renal disease patients receiving intravenous iron sucrose“ Iron from FeSO(4) plus AA was more rapidly absorbed, resulting in a 35% greater relative AUC during the first 2 h than for NaFeEDTA (P < 0.001).”
“In conclusion, bioavailability of iron from tofu is enhancedby supplementation with ascorbic acid.”
“Addition of mucoprotease and ascorbic acid to iron preparations is useful because it increases the compliance of the patients and thus also its effectiveness.”
“The mean lag phase to oxidation of low density lipoprotein (LDL) was significantly increased in subjects in Group B after 12 wk ingestion of iron and 260 mg vitamin C (from 80.0±14.8 min to 97.2±16.9 min; n=9).”
“The addition of vitamin C appears to enhance the therapeutic effect of iron by correcting ferritin deficits (P < 0.01) and anemia (P < 0.05).”
“The authors assessed the value of taking vitamin C with oral iron in correcting deficiencies in iron stores and anemia postoperatively.”
“While serum ferritin remained unchanged, transferrin saturation increased from 27 +/- 7 to 54 +/- 12% (P < 0.05), suggesting that ascorbic acid supplementation had allowed mobilization of iron from tissue burdens.”
“The marked inhibition of Fe absorption by phytates and the significant counteracting effect of ascorbic acid have wide nutritional implications.”
“Furthermore, ascorbic acid supplementation enhanced the toxic effects of iron , with the iron pool significantly increased in adult whole-body extracts.”
The effects of vitamin supplementation on Drosophila life span under normoxia and under oxidative stress.“ Ascorbic acid is often used to enhance iron absorption in nutritional interventions, but it produces pro-oxidant effects in the presence of iron.”
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