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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Iron, Dietary
drug:
Gentamicin
Research Papers that Mention the Interaction
“ Gentamicin has been shown to lead to release of iron from renal cortical mitochondria and to enhance generation of hydroxyl radical.”
Oxidant mechanisms in gentamicin nephrotoxicity.“The toxicity occurs via an activation process involving the formation of an iron– gentamicin complex with free radical production.”
The role of deferoxamine in the prevention of gentamicin ototoxicity: a histological and audiological study in guinea pigs“Results showed that animals receiving iron in combination with gentamicin demonstrated a more rapid and profound elevation in CAP thresholds compared with animals receiving gentamicin alone.”
“These results confirm that iron and free radicals play a crucial role in the toxic side effects of gentamicin.”
“This study confirms that iron plays a critical role in gentamicin ototoxicity and suggests that iron chelators, which are well-established drugs in clinical therapy, may be promising therapeutic agents to reduce aminoglycoside ototoxicity.”
“This study investigated the effect of supplemental dietary iron on the nephrotoxicity of GM.”
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