Possible Interaction: Iron, Dietary and Ferrous

“The addition of ferrous iron to the culture medium inhibited caspase‐3 activation and apoptotic nuclear morphologic changes and blocked 6‐OHDA‐induced cytotoxicity in SH‐SY5Y cells and primary cultured mesencephalic dopaminergic neurons.”

“In brain ischemia, the damaging role of iron may depend on the inhibition of detoxifying enzymes responsible for catalyzing the oxidation of ferrous iron.”

“Both the specific activity and the enzyme's iron content was significantly increased by the addition of ferrous ions to either the purified enzyme or to the insect cell culture medium during production.”

“ Iron is probably absorbed in the ferrous state (Moore, Dubach, Minnich and Roberts, 1944) and there is evidence that ascorbic acid facilitates the process (Moore, 1955).”

“An addition of ferrous iron to 5-ALA enhances heme biosynthesis and increases ATP production through an upregulation of the respiratory complex.”

“Several studies have reported that the administration of 5-ALA and ferrous iron to existing treatment improved the glycemic control in both patients with prediabetes and those with type 2 diabetes mellitus.”

“The results indicate that exposure to a combination of Fe and Cu in iron –steel workers induces oxidative stress.”

“The results show that iron uptake of the cells treated with Fe(II ) is significantly higher than that of the cells treated with Fe(III) (P<0.05).”

“We hypothesized that ferrous iron and vitamin C-containing supplements added to HM in vitro cause oxidation of milk fats, affect intracellular redox balance, and induce DNA damage.”

“Both isoforms of apoE stimulated formation of apoE-Abeta deposits and increased immobilization of iron in cultures treated with ferrous ions.”

“The action of epinephrine, eserine, cocaine and naphazoline hydrochloride is reduced or blocked by ferrous iron in three to sixty fold quantities.”