Possible Interaction: Iron, Dietary and Doxorubicin Hydrochloride

“ Doxorubicin can directly bind iron and can perturb iron metabolism by interacting with multiple molecular targets, including the iron regulatory proteins (IRP) 1 and 2.”

“Furthermore, doxorubicin prevents the mobilization of iron from ferritin by a mechanism that may involve lysosomal degradation of this protein.”

“The doxorubicin-mediated decrease in cFLIP(S) and XIAP and the TRAIL-induced apoptosis were prevented by pretreatment with an iron chelator, indicating that expression of these proteins was affected by free radical generation upon interaction of iron with doxorubicin.”

“The antineoplastic agent doxorubicin inhibits cell growth through mechanisms that include an interaction with iron , resulting in the generation of cytotoxic reactive oxygen species (ROS).”

“It is frequently suggested that iron is involved in doxorubicin and bleomycin toxicity.”

“In both cell types, incubation with doxorubicin DOX ) resulted in a significant (p < 0.004) accumulation of Fe in the storage protein, ferritin.”

“We showed that doxorubicin (DOX) and its analogs interfere with tumor and myocardial cell Fe metabolism by affecting the RNA-binding activity of IRPs.”

“The damaging effects of reactive oxygen species, generated by the interaction of doxorubicin with iron , play a critically important role in the pathogenesis of the chronic cardiotoxicity.”

“ Adriamycin significantly inhibited both cellular 59Fe uptake and Fe transport into the basolateral side.”

“It is proposed that such iron could interact with oxidants generated by certain drugs (e.g. adriamycin or daunorubicin) to facilitate tissue damage, and that some of the side‐effects of chemotherapy might be ameliorated by careful co‐administration of small doses of desferrioxamine.”

“Finally, we found that in the presence of iron , treatment with doxorubicin significantly increased the production of formaldehyde from dimethyl sulfoxide, an indication that the hydroxyl radical could be produced by intact tumor cells following anthracycline exposure.”