Possible Interaction: Iron, Dietary and Deferasirox

“ Deferasirox may therefore reduce unregulated tissue iron loading and prevent further end‐organ damage.”

“Results DFR significantly suppressed the intracellular Fe 2 + accumulation and cell death caused by hemin exposure.”

“Treatment with iron chelators (desferrioxamine, deferiprone, and deferasirox ) substantially improved cardiovascular morbidity and mortality in iron overloaded patients.”

“These effects could be partially attenuated by iron-chelation treatment with deferasirox , suggesting iron toxicity may have a negative impact on the hematopoietic microenvironment.”

“Recently, several studies using the iron chelators, O-trensox and ICL670A Deferasirox ), have demonstrated a decline in both iron and polyamine levels.”

“ Deferasirox showed the greatest antioxidant activity in the oxidation of ascorbic acid with the participation of iron ions and reduced the reaction rate by about a 100 times.”

“Furthermore, DFX appears to increase iron and other toxic metal absorption.”

“The new oral chelator deferasirox DFX ) increases iron excretion and decreases liver iron in TM and TI.”

“The combination of an iron chelator plus an antibiotic creates a novel form of synergism at 24 h. The antimicrobial effect of deferasirox may be ascribed to its ability to deplete iron that would otherwise be used for bacterial growth.”

“The use of deferasirox (DFRA) in HH and TI could cause an increase in iron and other toxic metal absorption.”

“ DFX administration steadily decreased her serum ferritin levels and chelated overloaded iron effectively.”