Possible Interaction: Iron, Dietary and Calcium Supplement

“It has been proposed that the 2 forms of iron enter a common pool in the enterocyte and that calcium inhibits the serosal transfer of iron into blood.”

“BACKGROUND Single-meal studies have established that calcium has an acute inhibitory effect on the absorption of iron.”

“Interpretation & conclusions: Supplemental levels of iron and calcium , both individually and in combination, significantly compromised the zinc status of experimental rats.”

“Results: The zinc status of experimental rats receiving supplemental levels of iron and calcium was significantly compromised.”

“Its high proportion of magnesium and/or calcium can impair the absorption of iron.”

“Whereas dietary calcium is known to reduce the bioavailability of iron , the molecular basis of this interaction is not understood.”

“In the present review, we re-evaluate recent data on NTBI (non-transferrin bound iron ) uptake that suggest a strict interplay with the mechanisms of calcium control.”

“In end-stage renal disease, patients' overtreatment with iron enhances the pre-existing risk for infectious complications caused by dialysis procedure per se, malnutrition, increased intracellular calcium , as well as low and high molecular weight uremic toxins.”

“Strong correlations (r > 0.90, p-value < 0.05) between Fe and other elements ( Ca , Mn and Pb) were found at both sampling sites.”

“Synergistic effects of aqueous Ca and Fe promote P stability reducing DIP mobility.”

“It was found that Fe also causes polyatomic interference with As in conventional ICP-QMS, in addition to Ca and Cl, and ICP-QMS/QMS can remove these interferences in mass-shift mode using O2 as reaction gas.”