Possible Interaction: Iodine and Tyrosine

“The remaining iodine readily iodinates the tyrosine and so neutralizes its own high oxidant power.”

“In large doses, I temporarily inhibits binding of I to tyrosine and the release of thyroid hormone by the gland.”

“The addition of an iodine molecule to the tyrosine in position 4 of Ang 1–7 drastically changes the binding characteristics of this peptide making it unsuitable for characterization of Ang 1–7 receptors.”

“The amount of iodine incorporated to tyrosine was not equivalent to the H2O2 generated by the monoamines nor to that exogenously added.”

“Further, three tyrosines are in a less polar medium, while three (or four) tyrosines are inaccessible to iodine.”

“The iodine consumption in the reaction with l-tyrosine increased significantly with an increase of the amount of adsorbed iodine.”

“From an initial role as membrane antioxidant and biochemical catalyst, spontaneous coupling of iodine with tyrosine appears to have created a versatile, highly reactive and mobile molecule, which over time became integrated into the machinery of energy production, gene function, and DNA replication in mitochondria.”

“We have studied the capacity of different iodinated derivatives of phenylalanine and tyrosine to inhibit the incorporation of [3H]tyrosine into tubulin catalyzed by tubulin:tyrosine ligase.”

“I- and H2O2, in addition to their function as primary substrates …, may act as alternative 'iodine acceptors' and therefore compete with tyrosine for the active iodinating agent, irrespective of whether this compound is an enzyme-… cation (E X I delta +) or an equivalent oxidized iodine species (IOH, IC1, I2).”

“Under these conditions the reactivity of the iodine to tyrosine at position 13 is found to be 4-fold that of the tyrosine at position 10.”