Possible Interaction: Iodine and Tretinoin

“In the SH-SY5Y cells, 200 μM I2 caused a 100-fold (0.01 µM) reduction in the antiproliferative dose of ATRA and promoted neurite extension and neural marker expression (tyrosine hydroxylase (TH) and tyrosine kinase receptor alpha (Trk-A)).”

“In vivo, oral I2 supplementation (0.025%) synergized the anti-tumor effect of ATRA (1.5 mg/Kg BW) and prevented side effects (body weight loss and diarrhea episodes).”

“Treatment with I μM RA decreased the levels of the various differentiation markers in cells cultured in either FBS or DLS as revealed by labelling of permeabilized cells and by immunoblotting of cell extracts using specific monoclonal or polyclonal antibodies.”

“… ATRA inhibited HSCs proliferation and diminished … collagen genes [procollagen α1 ( I ), procollagen α1 (III)] and profibrogenic genes (TGF-β1, CTGF, MMP-2, TIMP-1, TIMP-2, PAI-1), and significantly … expression of MMP-3 and MMP-13 in HSCs by suppressing the mRNA expression of JNK and AP-1.”

“CRABP I ) also functions in the catabolism of retinoic acid to modulate its concentration in the cell.”

“ ATRA also increased the uptake of iodine by SW1736 cells (P<0.01), and similar results were observed in β-catenin shRNA cells.”

“ Retinoic acid to a larger extent than retinol has been shown to alter the (1) membrane permeability to K + , I - , and glucose, (2) electrical conductivity of planar bimolecular lipid membranes, (3) membrane acyl chain order, and (4) oxidative phosphorylation of coupled mitochondria.”