Possible Interaction: Iodine and Thyroglobulin

“ Tg negatively correlated with increasing intake of iodine in population that do not suffer from thyroid disease, while a more than adequate to excessive iodine intake leads to an increase in Tg.”

“As was shown in a mouse model, high iodine supply leads to changes in the immunogenicity of the thyroglobulin molecule , upregulation of vascular intercellular adhesion molecule-1 (ICAM-1), and reactive oxygen species (ROS) generation in the thyrocytes.”

“We suggest, therefore, that the presence of iodine increases the autoantigenic potency of thyroglobulin , a major pathogenic antigen in the induction of autoimmune thyroiditis.”

“The presence of hormonogenic sites of different affinities for iodine allows thyroglobulin to modulate adaptively its hormonogenic capacity to external iodine supply.”

“All these suggested that iodinated TG inhibited the expression of NIS by PLC-PKC pathway and promoted NIS expression via the cAMP-PKA pathway.”

“Fourteen patients (93.3%) had stimulated thyroglobulin concentrations below 2 ng/mL after the first treatment with radioactive iodine.”

“ Tg is a more sensitive biomarker of iodine status in pregnancy than is TSH.”

“ Thyroglobulin concentration decreased by 24% and 13% of baseline in the iodine and selenium plus iodine groups in comparison with the placebo group (P = 0.009 and P = 0.108, respectively).”

“It was suggested that iodine increase the autoantigenic potency of thyroglobulin , a major pathogenic antigen in the induction of autoimmune thyroiditis.”

“Under nonenzymatic conditions of coupling the oxidized species of iodine or of diiodotyrosine would also catalyze the oxidation of the two hormonogenic iodotyrosine residues present at the surface of the molecule of thyroglobulin.”