Possible Interaction: Iodine and Povidone-Iodine

“He developed a delayed cutaneous reaction after receiving an iodinated radiographic contrast media and at the same time topical disinfection with povidone-iodine.”

“We report a case of intoxication by iodine in a man of 68-year-old after subcutaneous irrigations of Betadine at a concentration of 20% for a subcutaneous infection of the thigh.”

“The long-term use of PVP-I for gargling should be avoided by (1) people with a high risk of developing thyroid dysfunction due to the excessive intake of iodine , (2) pregnant women and (3) breast-feeding mothers.”

“Total iodine serum levels increased considerably after peritoneal lavage with PVP-iodine.”

“… PVP-I cream at 18 h resulted in a total reduction of 99.8 per cent in viable ….f.u./g of tissue) within 48 h. Comparing the in vitro bactericidal time of povidone iodine ointment with cream against Pseudomonas aeruginosa, Staphylococcus … the ointment.(ABSTRACT TRUNCATED AT 250 WORDS)”

“In fact, release of free iodine becomes more difficult when povidone-iodine concentration is high and diluting the solution facilitates free iodine release.”

“In addition, PVP-I significantly inhibited the proliferation of human MCF-7 breast carcinoma, IPC melanoma, and A549 and H1299 lung carcinoma cells in a concentration corresponding to 20 µM I2.”

“ Povidone-iodine binds iodine so firmly that insufficient free iodine is released to be effective for treating or preventing infection.”