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“It was suggested by Scott et al. (3), on the basis of work in rats, that phenylbutazone combines with iodine in the body and thus prevents it from being taken up by the thyroid.”
The Journal of clinical endocrinology and metabolism • 1957 | View Paper
“Nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin, phenylbutazone and oxyphenbutazone are known to potentiate ( I , 4, 5) and indomethacin and ibuprofen are known to antagonise the hypoglycaemic effect of oral sulphonylurea drugs (2).”