Possible Interaction: Iodine and Penicillins

“ I have found that, provided the risks and benefits of splenectomy are clearly explained, patients comply very carefully with prophylaxis with penicillin.”

“However, a synergism of penicillins with drugs acting similarly on the complement system, such as iodinated radiographic contrast media, may be expected.”

“No doubt with the advent of penicillin that danger has been considerably modified but that is … should face clearly the lessons that accrue from past experience under less favourable conditions and I certainly … that penicillin therapy permits of laxity either in bacteriological investigation … sound principles of treatment (Kenny, 1945).”

“ Penicillin has been reported to cause alterations in the bacterial metabolism of amino acids ( I ), peptides (2), nucleotides (3), and a unique series of molecules containing both nucleotides and peptides as well as hexosamine (4).”