“Our results show that, … introduction of an iodine atom on the … of nonivamide causes a decrease in the antioxidant activity, and this effect is sensitive to the position of iodine on … ring, with 5IN substantially retaining the efficacy of nonivamide to protect linoleic and cholesterol against free radical attack.”
“The introduction of an iodine atom on the vanillyl moiety of nonivamide causes a switch in the vanilloid activity (TRPV1 antagonism versus TRPV1 desensitization) and nullifies the aversive properties of capsaicinoids.”