Possible Interaction: Iodine and Methimazole

“This includes 1) inhibition of the iodine-…), 2) blockage of organic binding of iodine and coupling of iodothyronines to … (T3) (e.g., sulfonamides, thiourea, methimazole , and aminotriazole, among others), and 3) inhibition of thyroid hormone secretion by … of active hormone from the colloid (lithium or an excess of iodide).”

“This includes: (1) inhibition of the iodine …); (2) blockage of organic binding of iodine and coupling of iodothyronines to form … (T3) (e.g. sulfonamides, thiourea, methimazole , and aminotriazole, amongst others); (3) inhibition of thyroid hormone secretion by an … active hormone from the colloid (lithium or an excess of iodide).”

“ Methimazole inhibits the formation of iodinated origin material by both normal and MPO-deficient leukocytes.”

“Regardless of whether or not its administration … by the administration of large doses of methimazole, iodine induced a rapid decrease in serum T(4)-(127)I concentration which could not be explained by … peripheral turnover of T(4), as judged from the metabolism of the (131)I-labeled hormone.”

“ Methimazole acts in a manner similar to, if not identical with, thiourea and thiouracil and their derivatives, i. e., it prevents the binding of iodine to protein in the thyroid gland.”

“This iodinating activity was dependent upon a hydrogen peroxide-generating source and was inhibited either by boiling tissue or by the addition of methimazole.”

“A highly significant positive linear correlation was found between the thyroid oxidation of methimazole to sulfate and intrathyroidal iodine content.”

“The principal intrathyroidal effect of methimazole is shown to be due to its reactivity with elemental iodine.”

“Interaction of methimazole (MMI, 1-methyl-imidazole-2-thione) with I2 in solvents having different polarity gives two new stable compounds containing a dication disulfide and a monocation disulfide arranged in dimers, respectively.”