Possible Interaction: Iodides and Thyroxine

“There data clearly demonstrate that the combination therapy with Levothyoxine and iodide significantly improves prophylaxis of goiter recurrence.”

“Grey-scale values (by ultrasound, computer-aided estimation) after nine months were significantly … after 150 micrograms of iodide as well as after combined treatment with levothyroxine … iodide there were marked decreases of grey-scale values; this is interpreted … which takes place after iodide supplementation.(ABSTRACT TRUNCATED AT 250 WORDS)”

“In LISA study a combined therapy of levothyroxine and iodide resulted in an at least 50 % reduction of nodular volume in 21,6 % of treated patient compared to in only 5,2 % of placebo-treated patients.”

“Under L-thyroxine therapy the IC further decreased (243 +/- 144 micrograms/g), whereas patients receiving iodide showed an increase of the IC (570 +/- 197 micrograms/g).”

“It is concluded that 1 mg or 2 mg iodide a … normal human thyroid gland and suggested that these physiological doses of iodide … thyroxine secretion, representing a form of autoregulation of the thyroid cell, since it was … no evidence of pituitary mediation could be evidenced in the experimental protocol.”

“These data suggest that: (1) … under TSH control; (2) iodide … T4 and T3 release without affecting Tg secretion; (3) thyroidal injury results in marked increases in serum Tg concentrations; and (… determinations may be useful in predicting remission in patients with hyperthyroidism due to Graves’disease treated with antithyroid drugs.”

“Responses of T4 but not of T3 to TRH were also reduced after iodide.”

“Basal serum T4 concentrations and T4 release were diminished after prolonged administration of iodide in the nine subjects on the basis of an intraindividual comparison.”

“It is … that iodide may have inhibited the rate of thyroxine release, but the net loss of radioactivity suffered from failure of glandular reincorporation of radioiodide in some patients may have exceeded the fraction of retained 131I and thereby resulted in the pattern of an accelerated release of radioactivity.”

“inhibit the incorporation of inorganic iodide into diiodotyrosine and thyroxine (Franklin and Chaikoff, 1944; Franklin, Chaikoff, and Lerner 1944).”