Possible Interaction: Iodides and Thyroglobulin

“ Tg coordinately regulates both basal and apical iodide transporters in thyroid follicular cells.”

“Evidence is presented that free iodide in the reaction medium during iodination of thyroglobulin by lactoperoxidase or thyroidperoxidase in vitro and a limiting H2O2 supply actively regulates the efficiency of the simultaneously occurring synthesis of iodothyronines.”

“These compound act inhibiting the oxidation of iodide and iodination of monoand diiodotyrosine as well as iodotyrosine coupling and thyroglobulin biosynthesis.”

“A crucial step in thyroid hormone synthesis is the oxidative coupling of iodide to thyroglobulin that is catalyzed by thyroperoxidase.”

“To the Editor.— In small doses, inorganic iodide can function to inhibit thyroglobulin proteolysis.”

“This action of iodide is generally ascribed to inhibition of thyroglobulin proteolysis but supporting evidence is meager.”

“These results suggest that Tg is a strong suppressor of the expression and the activity of DUOX2/DUOXA2, thereby regulating iodide organification and hormone synthesis in the thyroid.”

“ Iodide concentrations higher than 0.5 µM daily added to the basal medium inhibited iodination of thyroglobulin and hormonosynthesis.”

“The present results show an inhibitory effect of excess iodide on TSH-stimulated thyroglobulin biosynthesis in FRTL-5 cells.”

“ Iodide added in vitro altered the distribution of label in prelabelled thyroglobulin in a way that suggested increased coupling in the thyroglobulin molecule.”

“The inhibitory effects of iodide and lysosomotrophic agents such as NH4Cl and chloroquin on thyroglobulin hydrolysis were additive suggesting different sites of action.”