Possible Interaction: Iodides and Thiouracil

“In humans, the thyroid/plasma iodide concentration ratio in the presence of thiouracil , which blocks hormone synthesis but not iodide accumulation, is about the same as the S/P ratio for the mixed saliva.”

“Administration of an anti-thyroid drug thiouracil ) leads to a decrease of iodide in the thyroid gland, while there is an increase in its concentration in the salivary glands.”

“Furthermore, the inhibitory effect of thiouracial was antagonized by concurrent administration of iodide.”

“It is suggested that both thiouracil and reduction in the environmental temperature inhibit the enzymatic oxidation of iodide to iodine in the gland, while thiocyanate reduces the uptake of iodide by thyroid tissue.”

“ Thiouracil , on the other hand, leaves this mechanism unaffected but prevents the oxidation of iodide and its subsequent incorporation into protein molecules to form thyroglobulin.”

“Ferguson and Sellers (1949) found that the concurrent administration of iodide with thiouracil for short periods (2–6 weeks) lessened the goitrogenic effect and resulted in thyroid glands which were 20–30% lighter than those produced by the goitrogen alone.”

“Concurrent administration of iodide and thiouracil or propylthiouracil for two to six weeks results in thyroid glands which are 20 to 30 per cent lighter than those produced by the administration of thiouracil or propylthiouracil alone.”

“The thyroid follicles of the rats receiving iodide with thiouracil contain more colloid and show less hyperplasia.”