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“Stimulation of iodide uptake by TSH was inhibited by the simultaneous presence of low concentrations of hCG while activity was restored with high concentrations.”
The Journal of clinical endocrinology and metabolism • 1992 | View Paper
“ Iodide accumulation increased after 2-h exposure to 5 IU/ml hCG , to 6-fold over the basal level after 8 h. This effect was reproduced using forskolin, the cAMP analog (Bu)(2)-cAMP, and phorbol acetate.”
“ Iodide uptake proved to be the most sensitive indicator of the thyrotropic activity of hCG , with increases occurring at a concentration of 10 mg/L. Acting as a partial agonist, hCG was also capable of dose-dependently inhibiting TSH-stimulated cAMP formation.”