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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Iodides
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“The second-order rate constant of NO binding in the presence of plasma levels of I- , Br-, and SCN- is 1-2-fold lower compared to that obtained in the absence of these molecules and remains unaltered through the Cl- plasma level.”
Kinetic evidence supports the existence of two halide binding sites that have a distinct impact on the heme iron microenvironment in myeloperoxidase.“Indeed, NO donors downregulate TSH-induced iodide accumulation and organification in thyroid cells.”
Nitric oxide-repressed Forkhead factor FoxE1 expression is involved in the inhibition of TSH-induced thyroid peroxidase levels“The author of the letter is right that there is an inhibitory action of the endogenously produced NO on TSH-stimulated iodide uptake in the thyroid cell and thyroid hormone biosynthesis (5).”
Author's Reply“ Metal iodides intervene by way of the NOI reagent, as for I2, but other salts require a mechanism involving reaction between a metal-amine complex and NO, itself.”
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