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Last Updated: 3 years ago

Possible Interaction: Iodides and Methimazole

supplement:

Iodides

Research Papers that Mention the Interaction

The iodide organification step can be inhibited by propylthiouracil and methimazole , which are TPO enzyme inhibitors.
The Journal of clinical endocrinology and metabolism  •  2001  |  View Paper
These results indicate that in our patient population 15 mg MMI had a longer inhibitory effect on the organification of iodide than did 300 mg PTU, and that MMI was more rapidly effective in the treatment of Graves' hyperthyroidism.
The Journal of clinical endocrinology and metabolism  •  1987  |  View Paper
Iodide inhibited TSH- and thyroid-stimulating immunoglobulin-activated cAMP accumulation and this effect was reduced by methimazole , showing that, in this tissue, iodide, through an oxidized derivative, depresses the TSH-cAMP system.
The Journal of clinical endocrinology and metabolism  •  1980  |  View Paper
We have found that stimulation by TSH (5 and 50 mU/ml) of cAMP formation in thyroid slices from patients preoperatively treated with methimazole and iodide is significantly less than in slices from patients treated with methimazole alone.
The Journal of clinical endocrinology and metabolism  •  1978  |  View Paper
Iodide therapy resulted in a striking diminution in urinary radioiodine excretion in one patient receiving Tapazole , with a concomitant slowing in the decrease of thyroidal radioiodine without a reciprocal effect...
The Journal of clinical endocrinology and metabolism  •  1962  |  View Paper
Iodide inhibited the cellular release of H(2)O(2) and NADPH oxidase activity, effects prevented by methimazole.
Endocrinology  •  2003  |  View Paper
Incubation with methimazole and PTU resulted in a 20% and 25% decrease of iodide accumulation, respectively, whereas potassium iodide suppressed iodide accumulation by approximately 50%.
Thyroid : official journal of the American Thyroid Association  •  1999  |  View Paper
On the contrary, LBI increased as a function of iodide concentration up to 100 microM. Methimazole (MMI) inhibited the incorporation of iodide into both LBI and PBI, but higher concentrations of MMI were required to depress LBI as compared to PBI.
The Journal of biological chemistry  •  1990  |  View Paper
Protein binding of iodide was inhibited by methimazole (10(-3) M) in all experiments.
European journal of cell biology  •  1990  |  View Paper
The effects of iodide on basal and agonist-stimulated thyroid metabolism were blocked by methimazole (10(-3) M).
Endocrinology  •  1989  |  View Paper
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