Possible Interaction: Iodides and Iodine

“Supplementation of animal feed with iodine influences the iodine content of milk and therefore, in addition to salt iodination , provides another possibility for improving the human iodine supply.”

“Inhibition of iodide organification with PTU or MMI abolish the growth inhibitory effect of iodide indicating that an organified iodinated product is responsible for the growth inhibitory effect of iodide on thyroid cell proliferation.”

“Faced with an iodine excess, it throttles the transport of iodide into the thyroid cells, the rate-limiting step of hormone synthesis.”

“Due to possible transfer of iodide to the fetus associated with the risk of iodine-induced hypothyroidism, it is recommended to abstain from vaginal application of iodine during pregnancy.”

“The patient has to avoid iodine-containing medication and the possibility of additives of iodide in vitamin- or electrolyte-supplementation has to be considered.”

“ABSTRACT The inhibition of thyroidal organic binding of iodine by iodide (Wolff-Chaikoff effect) was studied in 15 euthyroid men.”

“In this report an analysis is given of the factors governing the uptake of iodine by the thyroid glands, … using data available in the literature, it is shown to be probable that the ingestion of small amounts of inorganic iodide would significantly reduce the … to concurrently inhaled radioactive iodine.”

“Urinary iodine concentration and iodine content in the thyroid glands increased after high consumption of iodide from NI to 100 HI (p < 0.05).”

“Administration of iodinated contrast medium interferes with iodide uptake in the human thyroid gland and compromises diagnostic thyroid scintigraphy and radioiodine treatment for 4-6 weeks.”

“These findings suggest that the inhibition of organic binding of iodine in the presence of excess iodide may be due to a diminished generation or a decreased availability of hydrogen peroxide in the thyroid.”