Possible Interaction: Intrinsic Factor and Vitamin B Complex

“It is suggested that the protective effect of vitamin B 12 on intrinsic factor is an important physiologic defense against autogenous digestion and that achlorhydria may be viewed as a desirable feature in patients whose gastric atrophy is sufficient to cause serious lack of intrinsic factor.”

“Absorption of ingested vitamin B 12 is facilitated by the action of gastric intrinsic factor.”

“Preliminary studies on two patients with pernicious anemia tend … the administration of massive single oral doses of Bifacton repeated at intervals of one week may imitate even more … results of parenteral treatment with injectable liver concentrates or vitamin B 12 than does the administration … concentrate in small daily doses.”