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Last Updated: 2 years ago

Possible Interaction: Intrinsic Factor and Vitamin B 12

supplement:

Intrinsic Factor

supplement:

Vitamin B 12

Research Papers that Mention the Interaction

Hog intrinsic factor binds 30.3 µg of vitamin B12 per mg of protein.
Hog nonintrinsic factor binds 25.1 µg of vitamin B12 per mg of protein.
The Journal of biological chemistry  •  1973  |  View Paper
Intrinsic factor also has been shown to promote uptake of vitamin B12 by rat liver slices2,3 and liver homogenates4.
Nature  •  1961  |  View Paper
It has been suggested that mutations in transcobalamin II ( TCN2) or gastric intrinsic factor (GIF) proteins can alter their binding efficiency to cobalamin or reduce the ability of their receptors to internalize them.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition  •  2019  |  View Paper
Clinicians also need to be alert to interference in vitamin B12 assays from intrinsic factor antibodies.
The Medical journal of Australia  •  2013  |  View Paper
This decreased activity could be the principal cause of the malabsorption of labelled cobalamin which was observed in the presence of intrinsic factor.
Journal of internal medicine  •  1994  |  View Paper
The dihydroxy bile acids (deoxycholic, glycodeoxycholic, taurodeoxycholic, glycochenodeoxycholic, and taurochenodeoxycholic) inhibit the binding of intrinsic factor to vitamin B12 at physiological concentrations.
Gut  •  1981  |  View Paper
The anemia was caused by a selective malabsorption of vitamin B12 (Imerslund's syndrome), even in presence of intrinsic factor.
Anales espanoles de pediatria  •  1978  |  View Paper
The presence of free intrinsic factor in the small intestine has considerable physiological significance in maintaining the enterophepatic circulation of vitamin B12.
Gastroenterology  •  1976  |  View Paper
The reaction between cyanocobalamin and intrinsic factor was exothermic, ΔH ° being —22.7 kcal/mole and ΔS ° —31 cal/degree per mole.
Biochimica et biophysica acta  •  1971  |  View Paper
Why does the absorption of vitamin B12 require the mediation of intrinsic factor?
British medical journal  •  1971  |  View Paper
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