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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Intrinsic Factor
supplement:
Vitamin B 12
Research Papers that Mention the Interaction
“ Hog intrinsic factor binds 30.3 µg of vitamin B12 per mg of protein.”
“ Hog nonintrinsic factor binds 25.1 µg of vitamin B12 per mg of protein.”
Isolation of gastric vitamin B 12 -binding proteins using affinity chromatography. II. Purification and properties of hog intrinsic factor and hog nonintrinsic factor.“ Intrinsic factor also has been shown to promote uptake of vitamin B12 by rat liver slices2,3 and liver homogenates4.”
“It has been suggested that mutations in transcobalamin II ( TCN2) or gastric intrinsic factor (GIF) proteins can alter their binding efficiency to cobalamin or reduce the ability of their receptors to internalize them.”
“Clinicians also need to be alert to interference in vitamin B12 assays from intrinsic factor antibodies.”
“This decreased activity could be the principal cause of the malabsorption of labelled cobalamin which was observed in the presence of intrinsic factor.”
“The dihydroxy bile acids (deoxycholic, glycodeoxycholic, taurodeoxycholic, glycochenodeoxycholic, and taurochenodeoxycholic) inhibit the binding of intrinsic factor to vitamin B12 at physiological concentrations.”
“The anemia was caused by a selective malabsorption of vitamin B12 (Imerslund's syndrome), even in presence of intrinsic factor.”
“The presence of free intrinsic factor in the small intestine has considerable physiological significance in maintaining the enterophepatic circulation of vitamin B12.”
“The reaction between cyanocobalamin and intrinsic factor was exothermic, ΔH ° being —22.7 kcal/mole and ΔS ° —31 cal/degree per mole.”
“Why does the absorption of vitamin B12 require the mediation of intrinsic factor?”
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