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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Interleukin-7
supplement:
Epigallocatechin Gallate
Research Papers that Mention the Interaction
“Because IL-2R subunits IL-2/IL-15Rβ- and γc are shared with IL-15R and γc is shared with IL-7R, we suspected that EGCG might also influence the signaling of IL-15 and IL-7 , the two key regulators in maintaining T cell homeostasis.”
“Results showed that EGCG suppressed IL-15 and IL-7 signaling ; further, EGCG not only inhibited the subunits in IL-15R and IL-7R shared with IL-2R, but also affected their proprietary α chains in a manner that aligns with an impaired signaling.”
Epigallocatechin-3-gallate inhibits expression of receptors for T cell regulatory cytokines and their downstream signaling in mouse CD4+ T cells.
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