Possible Interaction: Interferons and Vitamin A

“Recent data suggest that vitamin A modulates the expression of type I interferon receptor enhancing the antireplication effect of interferon‐α on hepatitis C virus (HCV).”

“Simultaneous treatment of cells with interferon and Aquasol A, Tween 80 or vitamin A also reduced the action of the interferon.”

“ Vitamin-A deficient infants had significantly reduced ex vivo production of IFN-γ , but also significantly higher circulating neopterin concentrations.”

“Thus retinoic acid (and retinol ) inhibited the stimulatory action of interferon (IFN) on monocyte membrane function, and this inhibition was reversed by beta-carotene; beta-carotene alone modestly potentiated IFN in this system.”

“ Retinol and retinoic acid were found to be antagonistic to these effects of interferon and physiological concentrations were sufficient to inhibit changes in the monocyte membrane induced by relatively high concentrations of interferon.”

“Maternal feeding with 5,400 and 21,600 IU/kg VA decreased (P < 0.05) splenic interferon-γ (IFN-γ) transcripts and increased (P < 0.05) those of interleukin-2 (IL-2) in the progeny.”

“Repletion with vitamin A resulted in IFN activities ranging from 80 to 130% of controls.”

“Retinyl acetate (acetate ester of vitamin A) and retinal vitamin A adehyde) only slightly inhibited interferon activity , while retinoic acid (vitamin A acid) and retinol (vitamin A alcohol) were similarly effective at inhibiting interferon activity.”

“Simultaneous treatment of mouse cells with interferon and vitamin A (retinoic acid) resulted in an inhibition of interferon action.”

“ Vitamin A (retinoic acid) suppressed interferon production by L cells infected with Newcastle disease virus (NDV).”