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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Interferons
supplement:
Trypsin
Research Papers that Mention the Interaction
“Unlike animal cells, the bacteria do not require pre-treatment with actinomycin D. The interferon translated by bacteria is inactivated by trypsin and resistant to ribonuclease.”
Translation by bacterial cells of messenger RNA for interferon of animal origin.“ Trypsin treatment of cells prior to the exposure to interferon decreased the amount of interferon bound.”
“The destruction of the interferon molecule or of ‘associated proteins’ by trypsin abolished the blocking effect.”
“Both the anti-cellular and the anti-viral activities were markedly reduced by pretreatment of the interferon preparations with trypsin , sodium periodate or by heating at 60° for 1 hr.”
“Both interferons were inactivated rapidly by treatment with the endoproteases trypsin , pepsin, bromelain, and subtilisin.”
“ Trypsin treatment of nuclei decreased IFN binding by 80%, suggesting that the putative nuclear receptors are protein.”
Murine interferon-beta receptor-mediated endocytosis and nuclear membrane binding.“ Trypsin was found to inhibit interferon production levels in the same way as did the serum of newborn mice.”
“The macrophage-activating factors contained in lymphokine and interferon preparations were stable at pH 2 and at 56 degrees, but they were destroyed when heated at 80 degrees for 30 min, and were inactivated by trypsin.”
“Inactivation of the antiviral activity of the interferon by heating or digestion with trypsin also abolished the effect on cell-free protein synthesis.”
“Treatment with trypsin after incubation with interferon at 1�C inhibited development of antiviral activity.”
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