supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Interferons
supplement:
Tretinoin
Research Papers that Mention the Interaction
“Synergism between retinoids and interferon in tumoural cell lines have been demonstrated.”
13-cis retinoic acid in head and neck cancer chemoprevention: results of a randomized trial from the Italian Head and Neck Chemoprevention Study Group.“ PURPOSE Retinoids and interferons (IFNs) have single-agent and synergistic combined effects in modulating cell proliferation, differentiation, and apoptosis in vitro and clinical activity in vivo in the head and neck and other sites.”
“ All-trans retinoic acid added to peripheral blood mononuclear cells from untreated patients with MS or from controls potentiates this ability of interferon beta-1b to augment CD8 suppressor cell function in vitro.”
“This combination of retinoid and interferon is not recommended for further study in RCC.”
“… retinoids … interferons (IFNs) has been shown to have an enhancing effect on the induction of cell differentiation and on the suppression of cell proliferation as seen … testing a combination of isotretinoin (13-cis-retinoic acid), IFN-a, and a-tocopherol for advanced premalignant lesions in the head and neck.”
“Simultaneous exposure to retinoids and interferons can result in enhanced antiproliferative and differentiating effects on malignant lesions.”
“Therapy with RA decreased interferon gamma-secreting cell counts, had a minimal positive effect on T suppressor cell function, and had no effect on T-cell proliferation.”
“When RA and interferon beta-1b … combined, the inhibitory effect of RA on interferon gamma-secreting cells predominated, T suppressor cell function increased synergistically over the increment observed with interferon beta-1b use alone, and the inhibitory effect of interferon beta-1b alone on T-cell proliferation remained unchanged.”
“The combination of interferon and retinoic acid has significant activity in patients with squamous cell carcinoma.”
“ Retinoic acid has been claimed to improve such a response rate when combined with interferon.”
“To improve the results of interferon monotherapy, combinations of IFN with oral photochemotherapy (PUVA) or retinoids were investigated in nonrandomized trials showing higher response rates.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback