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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Interferons
supplement:
Phenylalanine
Research Papers that Mention the Interaction
“It could be concluded that the substitution of Phe in the codon 101 position, which may increase the binding activity of IFNβ with its receptors and introduction of an additional N glycosylation site (Asn-X-Thr) in the position 27 of IFNβ protein may cause such an effect.”
Targeted mutations in Val101 and Arg27 interferon beta protein increase its transcriptional and translational activities.“Further, combination of the MOP derivatives Phe , Val or Leu conjugates) with interferon (IFN)-α inhibited HCV replication more than IFN-α treatment alone.”
“The production of cytokines which are involved in the regulation of the cytotoxic process (tumour necrosis factor‐α, interferon‐γ , IL‐10, IL‐12 and transforming growth factor‐β1) was also affected by pHe , as their release was strongly inhibited at pHe 7·0.”
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