Possible Interaction: Interferons and Methionine

“Retinoic acid (RA) and methionine were studied for their relative effectiveness in enhancing the ability of interferons (IFNs) to reverse the phenotype of murine methylcholanthrene (MCA)-transformed cells and human osteosarcoma (OHA) cells.”

“To confirm whether M inhibits viral RNA-induced IFN signaling, we treated the M-transfected cells with intracellular poly(I:C) and found that M reduced IFNβ signaling activation (Fig. 1b).”

“Pulse labeling experiments with [35S] methionine show a marked change in the de novo synthesis of several proteins in the course of interferon treatment.”

“The expression of M alone potently inhibited reporter gene expression from a viral and an interferon (IFN)-inducible promoter, whereas P and NV did not produce a similar effect.”

“Evaluation of reciprocal dose-response curves of IFN and cholera toxin shows that treatment with toxin concentrations as low as 10 13 M induces a major inhibition of IFN effects.”

“Although interferon reduced the growth rate and the proportion of cells in both the M and S phases (mitotic index and labelling index), there were no appreciable differences in the duration of these phases between control and interferon-treated cells.”

“In this study, Met was found to diminish the activation of the mitogen-activated protein kinase signaling pathway; decrease the production of tumor necrosis factor-α, interleukin-6, and interferon-β ; and enhance the levels of intracellular SAM after lipopolysaccharide (LPS) treatment in macrophages.”