Possible Interaction: Interferons and Leucine

“Additionally, the RNA products of RNase L cleavage can upregulate interferon expression, via signaling through RIG-I-like receptors, and stimulate NLRP3 inflammasome activation.”

“ L , a small zinc-finger protein, restricts the production of interferon.”

“Overexpression of human RNase L greatly enhanced both the cell growth inhibitory activity of IFN and the proapoptotic activity of staurosporine.”

“By regulating viral and cellular RNA expression, RNase L plays an important role in the antiviral and antiproliferative activities of IFN and contributes to innate immunity and cell metabolism.”

“ Interferon activates the transcription of a set of genes including dsRNA-activated protein kinase that suppresses protein synthesis and 2′-5′-oligoadenylate synthetase, which generates a product that activates RNase L to cleave RNA in a sequence-independent manner.”

“Subsequent addition of IFN-γ inhibited ICa, L for an additional 16.3 ± 4.4%.”

“Alpha interferon exhibited high antiviral activity against JEV; the expression of three interferon-stimulated genes (ISGs), ISG15, Mx2 and OAS L , increased significantly after interferon treatment.”

“Upon binding with its activator, 5'-phosphorylated, 2'-5' oligoadenylates (2-5A), RNase L plays an important role in the antiviral and anti-proliferative functions of IFN , and exerts proapoptotic activity independent of IFN.”

“RNase L induction markedly enhanced the anti-EMCV activity of IFN via a reduction in EMCV RNA.”

“The 2'-5'oligo A (2-5A) synthetase/RNase L is one of the pathways leading to translation inhibition induced by IFN treatment.”