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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Interferons
supplement:
Apigenin
Research Papers that Mention the Interaction
“We … phytochemical apigenin … interferon (IFN)-γ-induced PD-L1 upregulation by triple-negative MDA-MB-468 BC cells, HER2(+) SK-BR-3 BC cells, and 4T1 mouse … well as human mammary epithelial cells, but did not affect constitutive PD-L1 expression by triple-negative MDA-MB-231 BC cells.”
Apigenin inhibits the inducible expression of programmed death ligand 1 by human and mouse mammary carcinoma cells.“In this earlier study we reported that apigenin and certain structurally related hydroxyflavones inhibited tumor necrosis factor (TNF), interleukin-1 (IL-1), lipopolysaccharide, and interferon-γ (IFNγ) induced expression of the adhesion molecules intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin.”
“This study demonstrated that Apigenin treatment significantly suppressed IAV‐induced upregulation of retinoic acid‐inducible gene‐I (RIG‐I) expression, as well as the production of proinflammatory cytokines and interferons (IFN‐β and IFN‐λ1).”
Apigenin suppresses influenza A virus‐induced RIG‐I activation and viral replication
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