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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Interferons
supplement:
Andrographolide
Research Papers that Mention the Interaction
“ Andrographolide decreased interferon γ , interleukin (IL)‑23 and IL‑17A, however it increased IL‑4 in a dose‑dependent manner, as indicated by ELISA assay.”
Andrographolide affects Th1/Th2/Th17 responses of peripheral blood mononuclear cells from ulcerative colitis patients.“ Andrographolide also suppressed the activation of IRF3 and the expression of interferon inducible protein‐10 (IP‐10) induced by TLR3 or TLR4 agonists.”
Andrographolide suppresses TRIF‐dependent signaling of toll‐like receptors by targeting TBK1“Mechanistically, Andro inhibited arterial NF-κB activation and reduced the production of proinflammatory cytokines [CCL2, CXCL10, tumor necrosis factor α, and interferon-γ ] in the treated aortae.”
“Moreover, treatment of APE and ANDLE significantly elevated the production of interleukin-2 and interferon-γ in normal and Ehrlich ascites carcinoma-bearing animals.”
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