Possible Interaction: Interferon Gamma-1B and Tyrosine

“This would contribute to the enhanced tyrosine phosphorylation, nuclear translocation, and DNA-binding of STAT1 upon exposure of the cells to IFN-gamma in the Ras-transformed cells.”

“Upon IFN-gamma stimulation, the tyrosine phosphorylation of this mutant protein was further enhanced but was not down-regulated by protein tyrosine phosphatase in vivo.”

“ IFN-gamma induced a rapid tyrosine phosphorylation and nuclear translocation of STAT1 protein, which is involved in the binding to the GAS-2 site in the p11 promoter by EMSA analysis.”

“ IFN-gamma increased tyrosine phosphorylation in T84 cells at 24 h, including the EGFr.”

“Interferon-alpha (IFN-alpha) and IFN-gamma regulate gene expression by tyrosine phosphorylation of several transcription factors that have the 91-kilodalton (p91) protein of interferon-stimulated gene factor-3 (ISGF-3) as a common component.”

“Being consistent with this, IFN-gamma induced increased tyrosine phosphorylation and this was inhibited by genistein.”

“IFN-beta and IFN-gamma induced a strong increase of STAT1 and STAT3 tyrosine phosphorylation, while the effect of IFN-alpha was much weaker.”

“Indeed, in R3T3 cells, IFN-gamma treatment resulted in rapid activation of Janus kinase (Jak) 1, Jak2, and STAT1 via tyrosine phosphorylation.”

“Although activation, phosphorylation, and turnover of the CSF-1 receptor … CSF-1-induced increase in diacylglycerol production remained normal, IFN-gamma blocked CSF-1-stimulated activation of mitogen-activated protein …, Raf-1 kinase, increase in GTP-bound Ras and tyrosine phosphorylation, and activation of protein … C delta (PKC-delta).”